MFLI, VAEV, PRMX, ORFG, EXTI
KKUR, ZANE, SSN, GETA, ARTS, BDGR
Our Stocks to Watch today include BRAVADA / Muscle Flex Inc. (OTC: MFLI), Vanity Events Holding Inc. (OTCBB:VAEV), Precious Metals Exchange Corp. (OTC: PRMX), Orofino Gold Corp. (OTC: ORFG), Extensions Inc. (OTC: EXTI), ChromoCure Inc. (OTC: KKUR), Zanett Inc. (Nasdaq: ZANE), Samson Oil & Gas Ltd. (NYSE Amex: SSN), Genta Inc. (OTCBB: GETA), Artfest International Inc. (OTCBB: ARTS) and Black Dragon Resource Companies Inc. (OTC: BDGR).

FEATURED
COMPANY

MUSCLE FLEX INCORPORATED (OTC: MFLI)
Detailed
Quote: http://www.otcpicks.com/quotes/MFLI.php
Company
Profile: http://www.otcpicks.com/muscle-flex-inc.htm
Muscle Flex Inc. brings new products to market using direct response TV infomercials specializing in the health, fitness, wellness and hygiene sectors. As well, Muscle Flex Inc. develops and creates general television content for network and cable television distribution. Muscle Flex's corporate strategy is to develop new and innovative products for sale and distribution via its proprietary direct response marketing system and the creation of television media and shows for general network and cable broadcast.
MFLI
News:
April 6 - BRAVADA International's Red Carpet BRAVADA Couture / Muscle Flex VATA Brasil Launch Party with Kim Kardashian Rescheduled for Wednesday April 7, 2010 at The Whisper Restaurant and Lounge at The Grove in Los Angeles, California
BRAVADA / Muscle Flex (OTC: MFLI) (www.BravadaLtd.com) announced that its highly anticipated Red Carpet BRAVADA Couture / Muscle Flex VATA Brasil (www.MuscleFlexVATA.com) National Launch Party with Kim Kardashian has been rescheduled for Wednesday April 7, 2010 at The Whisper Restaurant and Lounge located at The Grove in Los Angeles, California. Due to unforeseen circumstances, the event needed to be rescheduled for Wednesday April 7, a day ahead of the previous April 8 date.
The BRAVADA / Muscle Flex VATA Red Carpet Launch Party is receiving a tremendous amount of national media attention with dozens of major media publications and television networks expected and confirmed to be in attendance.
This star studded event is the official launch celebration for the BRAVADA Couture Muscle Flex VATA Brasil Sports and Active Wear collection. Kim Kardashian aligned with BRAVADA / Muscle Flex to represent and promote the sassy and sexy Brasilian inspired Muscle Flex VATA Brasil Sports and Active Wear Collection.
In attendance will be Kim Kardashian, Kris Jenner, Bruce Jenner and from BRAVADA / Muscle Flex Danny Alex and Amy Langkamp, the cast of The Complete Package, Ken Collis and Tracy Keyser from TLK Fusion and a number of surprise celebrity guest appearances.
“This is Hollywood and we do not expect any problems associated with having to move the date of our launch party up by one day to Wednesday April 7," replied Danny Alex, CEO and founder of BRAVADA International. “Kim Kardashian is one of the most sought after personalities in the world and there are situations that we all have to roll with. Our official launch party for BRAVADA Couture Muscle Flex VATA is turning out to be an amazing success because so many positives are coming together for our launch. Kim Kardashian will certainly be the highlight and she has been fantastic to work with and align BRAVADA International with."
FEATURED
COMPANY

VANITY EVENTS HOLDING INCORPORATED (OTCBB: VAEV)
"Up 33.33% in morning trading"
Detailed
Quote: www.otcpicks.com/quotes/VAEV.php
Company
Profile: http://www.otcpicks.com/vanity-events/vanity-events.htm
Headquartered in New York, NY, Vanity Events Holding, Inc. is a holding company with numerous expanding lines of business. Utilizing their acquired trademark of America's Cleaning Company™, Vanity has established a cleaning company offering a full range of residential and commercial cleaning services. The Company also seeks out, licenses, develops, promotes, and brings to market various innovative consumer and commercial products.
VAEV
News:
March 23 - Vanity Events Holding, Inc. Announces Company Progress Report
Vanity Events Holding, Inc. (OTCBB:VAEV) ("Vanity") provided its shareholders with an overview of the Company's progress to date.
VANITY EVENTS HOLDING, INC.
Vanity Events Holding, Inc. is a holding company with two primary subsidiary companies, each with its own varied goals and objectives. The subsidiaries are Vanity Events, Inc. and America's Cleaning Company.
VANITY EVENTS, INC.
Vanity Events, Inc.'s main offices are located at 43 West 33rd Street, Suite 600 in New York City. In March 2010, Vanity Events, Inc.'s food division opened a satellite office in Queens, New York. The Company has 27 full-time, salaried employees — six in Products, five in Food, six in America's Cleaning Company — Franchising, and ten who work on corporate matters (accounting, human resources, management, operations, and information technology).
PRODUCTS DIVISION
Vanity Events, Inc. seeks out inventions, patents, and innovative products with the purpose of assisting the principles in developing and bringing those products to market. The product acquisition process is rigorous, including analyzing market research data, market trends, the ability of an individual product to significantly impact the market, and financial worthiness.
In November 2009, Vanity Events, Inc. partnered with the United Inventors Association as a corporate sponsor, giving the Company the opportunity to reach and assist inventors in a wide range of fields, while at the same time allowing the Company the opportunity to establish itself as a leader in the field of innovation.
The Company's Products Division is extremely selective in determining which products to accept. To date, the Company has reviewed hundreds of product concepts and models, of which fewer than one hundred have received non-disclosure agreements. Of those that received non-disclosures, the Company has rejected the majority after determining they were not financially worthwhile to pursue. The Company is currently in "active" status with 35 products.
FOOD DIVISION
Vanity Events, Inc. also has a Food Division which seeks out innovative food products in order to develop and bring those products to market, while also working as a distributor of food products to various institutions and restaurants.
To date, the Food Division has developed plans to sell a full line of 100% natural sorbet as well as frozen fruits grown and imported from Chile, and a full line of organic pastas — flavored and whole wheat — are planned as well. The food department has already secured a number of contracts with groceries, nursing homes, restaurants and schools, with plans to sell to other institutions including hospitals.
AMERICA'S CLEANING COMPANY — FRANCHISING DIVISION
In addition to product development, Vanity Events, Inc. also functions as the management company for the franchising plans of America's Cleaning Company. Using its licensed trademark of America's Cleaning Company™ and its recognizable logo of "Anna C. Clean", the Company plans to brand itself as the premier provider of residential and commercial cleaning on a national level, while utilizing its own proprietary, brand-name products.
In September 2009, the Company began working with a number of established firms in order to best develop the franchise model for America's Cleaning Company. The Homewood, Illinois-based iFranchise Group are the prime advisors of the Company, guiding the Company through the franchising process while helping the Company develop its franchise model. In October 2009, the Company began working with Waterstreet, a Vancouver-based technology company, to develop specialized, web-based business management software for the Company. This software will be used to estimate and schedule jobs, track inventory, run reports on revenue and costs, and will be used by every franchise, allowing the Company to track and analyze the data from franchise to franchise.
In November 2009, the Detroit-based Out of the Box Technology (formerly Technology in a Box) began developing customized Quickbooks®-based software, including a standard set of accounting guidelines to be used by each franchise. Out of the Box has also worked with Waterstreet to integrate the two technologies, allowing the Company to closely track and analyze the practices of its franchisees and to quickly assist the franchisees by promoting best practices and showing where improvements can be made.
In November 2009, the Company also began working with the Tulsa-based Intellevue, a mapping software company, to help map and establish territories for potential franchisees based on carefully examined demographic information.
AMERICA'S CLEANING COMPANY
America's Cleaning Company began as a division of Vanity Events, Inc. and became its own company in December 2009.
America's Cleaning Company is carrying out operations as a "corporate franchise prototype", designed to both determine best practices and to test the franchise management technologies in order to streamline and simplify them for potential franchisees.
The Company has performed services in the New York City boroughs of Manhattan, Queens, and Brooklyn; on Long Island; and in northern New Jersey. The number of jobs ACC has performed has steadily increased in five of six months, beginning with 10 jobs carried out in the month of September, growing to 109 jobs carried out in the month of March.
America's Cleaning Company has four full-time salaried employees, and utilizes part-time workers as needed to carry out its services.
In March 2010, the Company began a partnership with America Works, a nationally recognized agency which specializes in intensive, personalized employment services. America's Cleaning Company is able to hire pre-screened, quality employees directly through America Works.
FEATURED
COMPANY

PRECIOUS METALS EXCHANGE CORPORATION (OTC: PRMX)
Detailed
Quote: http://www.otcpicks.com/quotes/PRMX.php
Company
Profile: http://www.otcpicks.com/precious-metals-exchange.htm
Precious Metal Exchange Corp. is a publicly traded company that has a novel approach to gold and silver trading that offers the added convenience and safety of "high tech" bearer certificates. The company has smelting, minting, and plating facilities as well as high tech assay capabilities. Precious Metals Exchange Corp. is in the precious metals refining and recycling sector of the precious metals industry. The Company will provide a convenient, secure and efficient method for customers to sell items containing precious metals. Targeted direct marketing is used to identify potential customers, and a highly automated fulfillment process to ensure their satisfaction through high payouts and quick service. The Company will recycle customers' broken or unwanted jewelry and other items for gold, platinum and silver content, avoiding the risks and environmental costs of mining.
PRMX News:
March 30 -
Precious Metals Exchange Corp. Names Head of Business Development Department
Precious Metals Exchange Corp. (OTC: PRMX) announced the hiring of Jason Ford to head the business development department for PRMX. His duties will involve the coordinating of the move to the new Precious Metals Exchange location and completing the first phase of the Company's unique business plan.
Ford attended Northwood University in Dallas, Texas and graduated Magna Cum Laude with a BBA in Business Administration. While attending Northwood on a baseball scholarship, he earned Division I Baseball All American honors and still holds numerous league and school records including the Division I Triple Crown with a single season record batting average of .456. He was also elected to the All Conference Team each season of his playing career and was chosen Most Valuable Player for each season he participated while maintaining a perfect 4.0 GPA. Ford is listed in Who's Who in America.
Ken Dougherty, Chairman and President of Precious Metals, said, "We look forward to Jason coming on board. Jason's past working experience will be an asset to the company's Business Development Department."
Ford has been involved with Caritas Ranch BBQ since 1994 working in all phases of the Boerne, Texas meat packing plant. His business career also includes Territory Manager for Martin Fletcher & Associates in Dallas, as well as the Salad Bowl franchise operation headquartered in Dallas, TX. He is a Licensed Insurance Agent representing Benefit Architects and is in the process of obtaining his Broker-Dealer Certification.
Ford stated, "People need an option for asset protection and PRMX offers the only game in town. The response to PRMX's business plan has been overwhelming and I look forward to perfecting a product that is truly a capital preservation company with the least risk in the market place. PRMX is able to offer services previously unavailable to the consumer. People who are looking for the ultimate protection in these troubled times will find that PRMX has the products that they are looking for and every American needs."
FEATURED
COMPANY

OROFINO GOLD CORPORATION (OTC: ORFG)
Detailed
Quote: http://www.otcpicks.com/quotes/ORFG.php
Company
Profile: http://www.otcpicks.com/orofino-gold/orofino-gold.htm
Orofino Gold is a precious metals acquisition, exploration, and development company. The Company acquires and explores strategically-located precious metals properties in the historically rich gold bearing jurisdictions of Colombia and Mexico. To this end OROFINO has signed an option agreement to acquire several properties in Colombia. The Company is listed on the Pink Sheets under the symbol ORFG.
ORFG News:
March 30 -
Orofino Gold Corp. Announces Exceptional Results Validation due April 8th
Orofino Gold Corp. (OTC: ORFG) ("Orofino Gold" or the "Company") announces that the initial results from mineralized and un-mineralized material samples, as well as selected representative samples collected from its Colombian projects that ran higher than expected in gold, silver and copper will be re-assayed, these results will be available on or before April 8th, 2010. These results will form part of a future NI 43-101 compliant review of previous exploration and field data as well as recommendations and budgets.
FEATURED
COMPANY

EXTENSIONS INCORPORATED (OTC: EXTI)
Detailed
Quote: www.otcpicks.com/quotes/EXTI.php
Company
Profile: http://www.otcpicks.com/extensions-inc/extensions-inc.htm
Extensions, Inc. is a technology company creating revenue generating opportunities through the development and monetization of its portfolio companies and technologies including the conversion of social media activity into keyword Search Engine Optimized (SEO) traffic. Our portfolio companies include: Newswire.net, a social network of independent journalists writing and distributing news under a unified Newswire banner; Cancer.im, a social network for cancer patients offering support from the perspective of cancer survivors; and Overtise.com, a platform allowing businesses the ability of harnessing social media as a Search Engine Optimization tool.
EXTI
News:
March 24 - Jack Canfield Endorses Newswire Publishing's 'Confessions of a Bank Director' as a Must Read
Newswire.Net, a subsidiary of Extensions, Inc. (OTC: EXTI), announced that Jack Canfield, the co-author of the Chicken Soup for the Soul series has endorsed Dr. Barkat Charania's book titled "Confessions of a Bank Director: The Entrepreneurs Guide to Credit, Capital and Cash Flow" as a must read.
"It takes a special person to turn adversity into success and despair into hope — yet that is exactly what Dr. Charania has done with this book; it is a must read for anyone who considers themselves an Entrepreneur."
Newswire Publishing's "Confessions of a Bank Director" gives the reader the behind the scenes view of how a banker sees and values an entrepreneurial venture. This perspective is rare, given the light that very few books are written from that perspective and even fewer are written on how to reposition your venture to the light most favorable to the bank.
The book is tentatively scheduled for a November 1, 2010 launch and will be followed by book signing tours and lecture series.
ABOUT JACK CANFIELD
As the beloved originator of the Chicken Soup for the Soul® series, Jack Canfield fostered the emergence of inspirational anthologies as a genre — and watched it grow to a billion dollar market. As the driving force behind the development and delivery of over 100 million books sold through the Chicken Soup for the Soul® franchise, Jack Canfield is uniquely qualified to talk about success.
He is Founder and Chairman of the Canfield Training Group in Santa Barbara, California, which trains entrepreneurs, educators, corporate leaders and motivated individuals how to accelerate the achievement of their personal and professional goals.
Jack Canfield is also the founder of The Foundation for Self-Esteem in Culver City, California, which provides self-esteem resources and trainings to social workers, welfare recipients and human resources professionals.
Jack Canfield holds the Guinness Book World Record for having seven books simultaneously on the New York Times Bestseller List — beating out Stephen King. He even holds the Guinness Book World Record for the largest book-signing ever for Chicken Soup for the Kids Soul. And he's the only author to have won both the ABBY Award and the Southern California Book Publicist Award in the same year — honoring him as both an outstanding writer and a consummate book marketer.
STOCKS
TO WATCH
CHROMOCURE INCORPORATED (OTC: KKUR)
"Up 100.00% in morning trading"
Detailed
Quote: http://www.otcpicks.com/quotes/KKUR.php
ChromoCure develops and provides proprietary cancer detection systems. The Company owns its technology and provides its systems on a revenue sharing basis. The Company's proprietary ChromoCure CS200 Chromosomal Scanner system measure the unique genomic characteristic found in 100% of all cancers and never found in normal cells. The Company believes its technology has an effective accuracy of 100% for all cancers at all stages. The Company believes its technology superior and will become the gold standard for cancer detection worldwide. The Company's technology and cancer expertise also suggest non-toxic and non-invasive approaches to cancer therapy and cure research. The Company will release progress reports on these initiatives from time to time.
KKUR News:
March 30 -
ChromoCure Enters Into Technology Exchange and Collaboration Agreement With Genome Research Group to Acquire Therapeutic Modeling Protocols and Algorithms
ChromoCure, Inc. (OTC: KKUR) announced today the signing of a Joint Venture and Technology Sharing Agreement with Genome Research Group (GRG). Under the Agreement ChromoCure will have access to GRG's proprietary advanced therapeutic modeling protocols and algorithms utilizing hypothermic modulation and resonance for the non-toxic and non-invasive treatment of cancer.
GRG will have complete access to the Company's chromosomal scanner technology including a complex and innovative series of systems, processes, cell preparation techniques and diagnostic algorithms. GRG will use the company's technology for on-demand, real-time cancer progression analysis to monitor and determine treatment efficacy.
GRG's advanced Therapeutic Modeling Protocols, together with ChromoCure's landmark Chromosomal Scanning Technology, further strengthens the Company's leadership in Cancer Detection, Therapy and Cure, and puts new impetus to its groundbreaking Project Boveri: Finding the Cure.
The Agreement will provide ChromoCure access to the following:
* hypothermic modulation and resonance protocols
* systems engineering specifications for human and animal applications
* remission monitoring protocols, procedures, and remission predictors
* tumor therapeutic growth and remission projection models
* remission estimation and projection models
* cancer stage analysis measurement and prediction model
* animal tumor eradication models and remission protocol models
* animal metastasis prediction technology and equations
* metastasis remission protocol and projection analysis
* leukemia progression prediction and measurement, metastasis reversion procedures
The Agreement is a further step in the Company's transition to a focused Cancer Therapy and Cure Research & Development organization. The Company recently announced its accelerated Therapy and Cure initiatives through the launch of Project Boveri: Find the Cure, properly reflecting its pioneering role in cancer detection, therapy and cure and its increased research programs and collaborations.
The Company's proprietary Chromosomal Scanner systems have proven accurate and efficient in the measurement of the unique genomic characteristic found in 100% of all cancers and never found in normal cells. The Company's detection technology has been proven to have an effective accuracy of 100% for all cancers at all stages. This is superior to other detection approaches presently relied upon by pathologists, including genetic or protein biomarker detection.
ChromoCure's systems measure aneuploidy as the sole means of detecting cancer presence and measuring cancer progression. The system has a 100% effective accuracy rate. The Company recently published its collaborative clinical testing with a major cancer clinic.
ZANETT INCORPORATED (NASDAQ: ZANE)
"Up 78.26% in morning trading"
Detailed
Quote: http://www.otcpicks.com/quotes/ZANE.php
Zanett, Inc., an information technology company (IT), provides customized, IT solutions to Fortune 500 corporations, mid-market companies, and classified government agencies involved in homeland defense and homeland security in the United States. It operates in two segments, Commercial Solutions, and Government Solutions. The Commercial Solutions segment provides lifecycle, end-to-end business solutions, including services to initiate, develop, and implement e-business systems; application development; project management; business analysis; architecture design; package customization; testing and quality assurance, and implementation management; and implementation of enterprise resource planning, supply chain management, and customer relationship management systems. The Government Solutions segment provides software and satellite engineering services on government and aerospace satellite, and IT infrastructure contracts. The company was founded in 1992 and is based in New York, New York.
ZANE
News:
April 6 -
Zanett Record Q1 Contracts Signed Total $17.1 Million
New customers total 43%; healthcare equals 42%
Zanett, Inc. (Nasdaq: ZANE) announced that it has set an in-house corporate record for contracts signed in a single quarter since the Company was founded over 10 years ago. During the first 3 months of 2010, over $17.1 million dollars in new business has been closed. This amount is comprised of 57 different customers, with the largest customer being responsible for a $4 million mandate. The $17.1 million in deal closings currently reported for Q1 includes the earlier reported $12.0 million comprising of business closed in January and February 2010.
PAST 6 MONTHS EQUALS $30.8 MILLION IN NEW BUSINESS
During the past six months, over $30.8 million of business was closed. Chuck Deskins, President of Zanett Commercial Solutions stated, "I am not easily excitable, but all I can say is... Wow...! The 21 great people in our national salesforce have been doing a fantastic job across all segments and throughout all geographies. Over 43% of all new business closed in Q1 was with brand-new customers."
The greater part of the business that has been signed during the past 6 months will be recognized as revenue during the next 4 quarters.
AMERICA IS THRIVING ... SO IS ZANETT'S HEALTHCARE FOCUS
At Zanett, the Healthcare Sector was by far the biggest segment of contracts signed for the past 3 months, accounting for 42% of the value of all contracts signed. Over the past 6 months, more than $11.3 million of new business has been closed in the Healthcare Sector.
Dennis Harkins, President of Zanett Inc, said, "I have said it before and I will say it again ... America is thriving and business is booming ...! People are currently underestimating the magnitude of this economic recovery."
"Throughout the US, corporations are currently hesitant about hiring individuals, due to unknown and unfunded mandates from Washington DC, so they are spending their money on increased capital expenditures. For any corporation out there, Oracle ERP and other IT spending are a natural beneficiary of a reduction in labor force. Here at Zanett, we have a great national salesforce, and they can barely keep up with the demand they see."
SAMSON OIL & GAS LIMITED (AMEX: SSN)
"Up 48.53% in morning trading"
Detailed
Quote: http://www.otcpicks.com/quotes/SSN.php
Samson Oil & Gas Limited, together with its subsidiaries, engages in the exploration, development, and production of oil and gas properties in the United States. The company owns interests in various projects located in Wyoming, North Dakota, New Mexico, and Texas. Samson Oil & Gas Limited was founded in 1980 and is headquartered in Perth, Australia.
SSN News:
April 5 -
Samson Oil & Gas Advises the Gene #1-22H Interim Initial Rate at 1,112 Boepd from Partial Frac
Samson Oil & Gas Limited (NYSE Amex: SSN) (ASX: SSN) provides an Operational Update on the Gene #1-22H Well. As previously advised the Gene #1-22H well which is located in Williams County, North Dakota has been completed as a 5,500 foot horizontal well in the Mississippian Middle Bakken Formation.
Operations to fracture stimulate the well commenced on Wednesday, March 31st and Stages 1 and 2 were pumped on Thursday, April 1st; this was followed by Stages 3 through 5 which were pumped Friday and Saturday, April 2nd and 3rd. The completion design is for a 16-stage fracture stimulation so this initial operation amounts to approximately a third of the stimulation program.
Operations were suspended because of the Easter Sunday holiday and the well was flowed back whilst the service company crews were off site.
The initial flow back results from the first 5 of a planned 16 multi-stage frac were undertaken on Sunday, April 4th. The rate at 0600 hours on Sunday was recorded at 913 mscfd of gas and 960 bopd which is a combined rate of 1,112 boepd.
The flow back continued into Monday, April 5th and was recorded at 0800 hours on that day, at 650 mscfd of gas and 840 bopd which is a combined rate of 948 boepd.
The forward plan is to clean out some residual sand that was left in the well after Stage 5 using a coiled tubing unit. This interim clean out is planned for today, Monday, April 5th and the balance of the frac stages (Stages 6 through 16) will be pumped during the balance of this week. Following this, the well will be flowed back and the market will receive further advice on the results of the flow back of the entire well.
Gary #1-24H (37% working interest)
The operator of the North Stockyard field has proposed and permitted the Gary #1-24H well which is in the adjacent section to the Gene #1-22H well. Samson has yet to commit to drilling this well as we were waiting to see the results from the Gene #1-22H frac. However the initial interim results are encouraging and subject to finalizing the stimulation it is likely that Samson will elect to participate in the Gary #1-24H well. The exact timing of the well has yet to be determined but could be as early as mid May, or depending on the drilling sequence, mid June.
North Stockyard Field
Samson holds equity in 6 contiguous 640 acre sections associated with this project. Following the completion of the Gene and Gary wells, Samson will have drilled 3 of these sections using a 640 acre drilling spacing, leaving 3 additional 640 acre locations to be drilled. Given the expected drainage areas of these horizontal wells will be rectangular rather than square there should be a further 4 wells locations available to take the development spacing to a 320 acre drainage area.
The Operator has indicated that it intends to maintain the contract on the Nabors 668 rig and therefore Samson is expecting that the three additional 640 acre wells are likely to be drilled in the balance of 2010.
Samson’s Ordinary Shares are traded on the Australian Securities Exchange under the symbol "SSN." Samson's American Depository Shares (ADSs) are traded on the New York Stock Exchange AMEX under the symbol "SSN." Each ADS represents 20 fully paid Ordinary Shares of Samson. Samson has a total of 1,295 million ordinary shares issued and outstanding, which would be the equivalent of 64.7 million ADSs. Accordingly, based on the NYSE AMEX closing price of US$0.55 per ADS on April 5th, 2010 the company has a current market capitalization of approximately US$35.5 million. Correspondingly, based on the ASX closing price of A$0.026 on April 1st, 2010, the company has a current market capitalization of A$33.7 million.
GENTA INCORPORATED (OTCBB: GETA)
"Up 32.61% in morning trading"
Detailed
Quote: http://www.otcpicks.com/quotes/GETA.php
Genta Incorporated is a biopharmaceutical company with a diversified product portfolio that is focused on delivering innovative products for the treatment of patients with cancer. Two major programs anchor the Company’s research platform: DNA/RNA-based Medicines and Small Molecules. Genasense® (oblimersen sodium) Injection is the Company's lead compound from its DNA/RNA Medicines program. The leading drug in Genta’s Small Molecule program is Ganite® (gallium nitrate injection), which the Company is exclusively marketing in the U.S. for treatment of symptomatic patients with cancer related hypercalcemia that is resistant to hydration. The Company has developed G4544, an oral formulation of the active ingredient in Ganite, which has recently entered clinical trials as a potential treatment for diseases associated with accelerated bone loss. The Company is also developing tesetaxel, a novel, orally absorbed, semi-synthetic taxane that is in the same class of drugs as paclitaxel and docetaxel. Ganite and Genasense are available on a “named-patient” basis in countries outside the United States.
GETA News:
April 6 -
Genta's Tesetaxel Granted Fast Track Designation by FDA for Advanced Gastric Cancer
Genta Incorporated (OTCBB: GETA) announced that the U.S. Food and Drug Administration (FDA) has granted the Company’s request for “Fast Track” designation of tesetaxel for treatment of patients with advanced gastric cancer. Tesetaxel, a late Phase 2 oncology product, is the leading oral taxane currently in clinical development.
Fast Track designation is designed to facilitate the development and expedite the review of new drugs that are intended to treat serious or life-threatening conditions and that demonstrate the potential to address unmet medical needs. The designation typically enables a Company to submit a New Drug Application (NDA) on a “rolling” basis with ongoing FDA review during the submission process. NDAs with Fast Track designation are also usually granted priority review by FDA at the time of submission.
Based on promising results in a Phase 2a trial, Genta is conducting a confirmatory Phase 2b trial of tesetaxel as 2nd-line treatment in patients with advanced gastric cancer who have failed a single 1st-line regimen. As defined, the 1st-line regimen must comprise a platinum-containing compound (cisplatin, carboplatin, or oxaliplatin) and a fluoropyrimidine (5-fluorouracil, capecitabine, or S-1). The Fast Track designation targets the patient population that is enrolling in the Phase 2b trial.
Genta has formulated a trial design and clinical protocol for a randomized, double-blind, placebo-controlled Phase 3 trial of tesetaxel in this patient population. In developing the trial, the Company completed a dose-ranging and pharmacokinetic study of tesetaxel plus capecitabine (Xeloda®; Hoffmann LaRoche, Inc.). Results from that study showed that full doses of each of these orally administered drugs could be administered together without causing overlapping side-effects.
Genta plans to submit its proposed Phase 3 trial to FDA in the 2nd-quarter in order to secure a Special Protocol Assessment (SPA). The Company looks forward to meeting with the FDA to discuss the trial design.
ABOUT TESETAXEL
Taxanes (including paclitaxel and docetaxel) are the most widely used chemotherapy drug class in cancer medicine. However, these agents are associated with serious safety issues, particularly hypersensitivity reactions related to intravenous infusions that are occasionally fatal and that require careful premedication and observation. Other prominent side-effects of this drug class include myelosuppression (low blood counts) and peripheral neuropathy (disabling nerve damage).
Tesetaxel is a novel taxane that is administered by mouth as a capsule. The drug was developed with a goal of maintaining the high antitumor activity while eliminating infusion reactions, reducing neuropathy, and increasing patient convenience. The oral route also enables the development of novel schedules that may expand dosing options when tesetaxel is combined with other anticancer drugs (such as “all oral” chemotherapy programs). Tesetaxel has demonstrated high activity against cell lines that are resistant to paclitaxel and docetaxel.
As a late Phase 2 oncology product, tesetaxel has demonstrated anticancer activity in its initial clinical trials, and the drug has not been associated with the severe infusion reactions that are linked with conventional taxanes. Moreover, unlike other oral taxanes that have been developed, nerve damage has not been a prominent side effect of tesetaxel. Thus, the drug offers substantial opportunities to improve patient convenience, safety, and anticancer activity.
Tesetaxel in Advanced Gastric Cancer
In the completed Phase 2a study, 35 patients with advanced gastric cancer were treated with tesetaxel at doses ranging from 27 to 35 mg/m2 once every three weeks. All patients had received extensive prior treatment, having failed a combination regimen that included cisplatin plus 5-fluorouracil or capecitabine. All but 2 of these patients had also received a third chemotherapy drug along with this regimen. Final intent-to-treat analysis, including all patients enrolled in the study, showed that 5 patients achieved a partial response, 2 patients achieved a partial response unconfirmed by CT scan, and 14 patients achieved stable disease, for an overall major response rate of 20% and a disease-control rate of 60%. The most serious adverse reaction was Grade 3-4 neutropenia, which occurred in 57% of patients.
ARTFEST INTERNATIONAL INCORPORATED (OTCBB: ARTS)
"Up 70.73% in morning trading"
Detailed
Quote: http://www.otcpicks.com/quotes/ARTS.php
Artfest International, Inc. brings together artists, investors, decorators, designers, private collectors and art galleries. Artfest International's corporate site is www.artfestinternational.com. Artfest's subsidiaries are Art Channel, Inc. and Art Channel Galleries, Inc., which offer the most exciting product and rewards program in the history of direct sales marketing.
ARTS
News:
April 6 -
Artfest International, Inc. Signs Distribution Agreement with Second Largest Cable Operator in the Country
Time Warner Cable to Distribute Artfest International's New Artfest Direct Program
Artfest International, Inc. (OTCBB: ARTS) announced that Time Warner Cable will be the distribution outlet of Artfest International's "Artfest Direct" program to 550,000 Time Warner Cable customers. Artfest has an "On-Demand" distribution agreement with Time Warner, Inc., the second largest cable operator in the country, which will give Artfest International its base for the development of the Art Channel "On-Demand" program. Starting next month, Artfest will be showcasing its Art and Sports memorabilia, on its Time Warner Art Channel program slot. As part of the distribution agreement with Time Warner, Artfest is able to sell advertising/commercial space that is available on its Art Channel TV slot.
Time Warner Cable owns and manages cable systems connected to approximately 26 million homes in 33 states. The Company has 14.7 million customers for its video, high-speed data and residential telephone services. This includes 13.3 million basic video subscribers and more than 7 million customers who purchase at least two of the Company's primary services. Time Warner Cable operates some of the most technologically advanced and best-clustered cable systems in the country, with nearly 85 percent of the Company's customers located in five geographic regions: New York, Texas, Ohio, the Carolinas and southern California. It is the largest cable provider in the nation's two largest cities, Los Angeles and New York, and the second largest cable operator in the country.
"We are excited to launch our Art Channel on the second largest cable operator in the country," stated Edward Vakser, CEO of Artfest International, Inc. "After the successful launch of our Art Channel in Texas, we plan to expand our Art Channel nationwide by the end of 2010. We are pleased to have formed this relationship as we continue to increase our sales revenues and shareholder value."
Artfest International recently filed its notification of late filling for the Company's 10-K with the SEC for period ending December 31, 2009. The notification was due to the growth the Company has experienced over the past year which included the acquisitions of Charity Sports Distributor as well as various events held at Artfest International's 52,000 square foot facility in Dallas, Texas, and direct sales activity through its Art Channel, Inc. and Art Channel Galleries, Inc. subsidiaries. The Company expects its 10-K to be filed within the next 10 days.
BLACK DRAGON RESOURCE COMPANIES (OTC: BDGR)
"Up 13.33% in morning trading"
Detailed
Quote: http://www.otcpicks.com/quotes/BDGR.php
Black Dragon is an oil and gas exploration and production company currently focused on the acquisition of mature, producing and existing domestic oil and gas fields. This focus has eliminated exploration risk, reduced costs of completion, and provided rapid generation of income in a niche market where larger independent and major oil companies are not positioned to compete. Black Dragon intends to recomplete additional shallow producing wells and to expand its focus to include drilling of new wells, some to deeper levels, and to purchase additional leases.
BDGR News:
April 6 -
Black Dragon Resource Companies, Inc. Returns Wells to Production
Black Dragon Resource Companies, Inc.'s (OTC: BDGR) ("the Company", "Dragon") Chairman and CEO, Mr. Scott D. Smith announces that the company has initiated a strict regiment to return more wells than expected to production in its large portfolio of proven reserves. These achievements have been made possible due to favorable oil prices coupled with improved weather conditions. BDGR has substantially increased its current oil output 37.5% over last month's numbers at a time when oil prices historically increase through the Summer months. Production numbers have increased drastically over the last month's period and the company expects to see this trend continue throughout the dry season.
According to Mr. Smith, "Black Dragon Resource Companies, Inc., is committed to the continual development of our portfolio of proven reserves. BDGR is in a unique position to harvest its proven reserves on a low cost basis, therefore achieving historically above-average returns on our oil and gas properties. Favorable oil prices have created countless opportunities for Dragon in recent days due to our cost-effective business model accompanied by the foresight of the Board of Directors at Dragon to continuously seek new technology applications. We intend to announce several new and exciting opportunities and technologies to shareholders in the coming days and weeks ahead."
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